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| DAY–1 Tuesday, April 15, 2008 |
| 7:30 am - 8:00 am |
Registration |
| 8:00 am - 8:10 am |
Introduction and Goals
Dr. David A. Jett, NINDS
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Session 1: Cyanide (Chair: Dr. Gennady E. Platoff Jr., NIAID)
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| 8:10 am - 8:30 am |
US Army Research on Cyanide
Dr. Gary Rockwood, U.S. Army Medical Research Institute of Chemical Defense
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| 8:30 am - 8:50 am |
Countermeasures Against Chemical Threats: Countermeasures Against Cyanide
Dr. Steven E. Patterson, University of Minnesota
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| 8:50 am - 9:10 am |
Pre-Clinical and Clinical Studies of Cobinamide, a New Cyanide Detoxifying Agent
Dr. Gerry R. Boss, University of California, San Diego
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Session 2: Pulmonary Agents (Chair: Dr. Elizabeth A. Maull, NIEHS)
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| 9:10 am - 9:30 am |
US Army Research on Pulmonary Agents
Mr. Dana Anderson, U.S. Army Medical Research Institute of Chemical Defense
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| 9:30 am - 9:50 am |
Prevention and Treatment of Chlorine Gas Induced Injury to the Pulmonary System
Dr. Sadis Matalon, University of Alabama at Birmingham
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| 9:50 am - 10:10 am |
Functional Genomics of Chemical-Induced Acute Lung Injury
Dr. George Leikauf, University of Pittsburgh
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| 10:10 am - 10:30 am |
Novel Therapies for Chlorine-Induced Lung Injury
Dr. Gary W. Hoyle, University of Louisville
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| 10:30 am - 10:50 am |
Therapeutics Against Chemical Threat Induced Respiratory Toxicity
Dr. Madhusoodana P. Nambiar, Geneva Foundation
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| 10:50 am - 11:00 am |
Break
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Session 3: Vesicating Agents (Chair: Dr. Carl C. Baker, NIAMS)
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| 11:00 am - 11:20 am |
US Army Research on Toxic Vesicants
Dr. John Graham, U.S. Army Medical Research Institute of Chemical Defense
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| 11:20 am - 12:20 pm |
Novel Antioxidant Therapeutics for Sulfur Mustard Toxicity [Center Report]
Dr. Carl W. White et al., National Jewish Medical & Research Center
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| 12:20 pm - 1:30 pm |
Lunch
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| 1:30 pm - 2:30 pm |
Poster Session
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| 2:30 pm - 2:50 pm |
Detoxification of Electrophilic Chemical Threat Agents by Nucleophilic Scavengers
Dr. Michael C. MacLeod, University of Texas
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| 2:50 pm - 3:10 pm |
Sensory Neural Mechanisms of Pulmonary Agent and Vesicant Toxicity
Dr. Sven-Eric Jordt, Yale University
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| 3:10 pm - 4:10 pm |
Identification of Therapeutics for the Treatment of Sulfur Mustard Injury [Center Report]
Dr. Gary R. Grotendorst et al., Lovelace Biomedical and Environmental Research Institute
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| 4:10 pm - 5:10 pm |
UMDNJ/Rutgers University CounterACT Research Center of Excellence [Center Report]
Dr. Jeffrey D. Laskin et al., University of Med/Dent NJ-RW Johnson Medical School
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| 5:10 pm - 7:00 pm |
Poster Networking Session
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| DAY–2 Wednesday, April 16, 2008 |
| 8:00 am - 9:00 am |
Food and Drug Administration Q&A
Dr. Susan S. McDermott, Medical Officer
Office of Counterterrorism and Emergency Coordination
Center for Drug Evaluation and Research
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Session 4: Nerve Agents #1 (Chair: Dr. David A. Jett, NINDS)
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| 9:00 am - 9:20 am |
Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
Dr. Richard K. Gordon, Geneva Foundation
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| 9:20 am - 9:40 am |
Oxime-Assisted Catalysis of Organophosphates and Reactivation of AChE
Dr. Palmer W. Taylor, University of California, San Diego
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| 9:40 am - 10:00 am |
Induced Therapeutic Overexpression of Acetylcholinesterase in Vivo
Dr. Richard L. Rotundo, University of Miami
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| 10:00 am - 10:20 am |
Neuroprotective Roles for Neuregulins in Neurotoxin-mediated Neuronal Injury
Dr. Byron D. Ford, Morehouse School of Medicine
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| 10:20 am - 10:40 am |
Age and Sex Effects on Nerve Agent Damage to the Brain and Antidotal Therapies
Dr. Edson X. Albuquerque, University of Maryland at Baltimore
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| 10:40 am - 10:50 am |
Break
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| 10:50 am - 11:10 am |
US Army Research on Anticonvulsants and Neuroprotectants
Dr. Tony Shih, U.S. Army Medical Research Institute of Chemical Defense
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| 11:10 am - 11:30 am |
CounterACT Preclinical Development Facility
Dr. Carol Green, SRI International
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| 11:30 am - 11:50 am |
A First-Responder EEG Device for Seizure Management in a Nerve Gas Attack
Dr. Scott B. Wilson, PERSYST Development Corporation
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| 11:50 am - 12:10 am |
Automated Seizure Detection Following Nerve Agent Exposure
Dr. David L. Sherman, Infinite Biomedical Technologies, LLC
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| 12:10 pm - 1:30 pm |
Lunch
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| 1:30 pm - 2:30 pm |
Poster Session
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| 2:30 pm - 2:50 pm |
Field Deployable, Automatic, EEG Seizure Detector and Brain Dysfunction Monitor
Dr. Mohammad Modarres-Zadeh, Cleveland Medical Devices, Inc.
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| 2:50 pm - 3:10 pm |
Midazolam Clinical Trial
Dr. William Barsan, University of Michigan
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| 3:10 pm - 3:30 pm |
Anticonvulsant Screening Program
Dr. Steve White, University of Utah
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| 3:30 pm - 3:50 pm |
Prostanoid Modulators that Reduce Brain Injury and Inflammation After Seizures
Dr. Raymond J. Dingledine, Emory University
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| 3:50 pm - 4:10 pm |
Mechanism and Treatment of Nerve Agent-Induced Seizures
Dr. Jaideep Kapur, University of Virginia
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| 4:10 pm - 4:30 pm |
Counter Measures Against Acetylcholine Receptor Activated Status Epilepticus
Dr. Robert J. DeLorenzo, Virginia Commonwealth University
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| 4:30 pm - 4:50 pm |
Efficacy of GluR5 Antagonists Against Soman-Induced Seizures and Neuropathology
Dr. Maria F. Braga, Uniformed Services University of the Health Sciences
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| 4:50 pm - 5:10 pm |
Anticholinesterase Neurotoxicity is Mediated by Oxidative Injury
Dr. Dejan Milatovic, Vanderbilt University Medical Center
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| DAY–3 Thursday, April 17, 2008 |
| Session 5: Nerve Agents #2 (Chair: Dr. Joseph J. Pancrazio, NINDS) |
| 8:00 am - 8:20 am |
Targeted Paraoxonase Fusion Protein as a Neurotherapeutic for Nerve Gas Agents
Dr. Yufeng Zhang, ArmaGen Technologies, Inc.
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| 8:20 am - 8:40 am |
Novel Protein-Based Therapeutics for Nerve Agent Detoxification
Dr. Matthew Redinbo, University of North Carolina
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| 8:40 am - 9:00 am |
Catalytic Bioscavengers with Broad Specificity Against OP Nerve Agents
Dr. James Wild, Texas A&M University
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| 9:00 am - 9:20 am |
Novel Therapeutic Agent to Treat Nerve Agent Exposure after Civilian Attack
Dr. John K. Troyer, PharmAthene, Inc.
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| 9:20 am - 10:20 am |
Center for Catalytic Bioscavenger Medical Defense Research [Center Report]
Dr. David E. Lenz et al., U.S. Army Medical Research Institute of Chemical Defense
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| 10:20 am - 10:40 am |
Break
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| 10:40 am - 11:00 am |
A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
Dr. Yvonne J. Rosenberg, PLANTVAX, INC.
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| 11:00 am - 11:20 am |
Development of a Selective Biosensor for Detecting Organophosphate Exposure
Dr. Jon O. Nagy, ATERIS Technologies, LLC
Dr. Charles M. Thompson, ATERIS Technologies, LLC and University of Montana
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| 11:20 am - 11:40 am |
Fiber Grating-Based Chemoselective and Reversible Sensor Array
Dr. Kisholoy Goswami, Innosense, LLC
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| 11:40 am - 12:00 pm |
Mass Spectrometry in Clinical Diagnosis of Nerve Agent Exposure
Dr. Oksana Lockridge, University of Nebraska
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| 12:00 pm - 12:20 pm |
Innovative Biomonitoring Device for Rapid Diagnosis of Exposure to Nerve Agents
Dr. Yuehe Lin, Battelle Pacific Northwest Labs
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| 12:20 pm - 12:40 pm |
Biosensor for Real-Time Chemical Monitoring
Dr. John R. Cashman, Human Biomolecular Research Institute
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| 12:40 pm - 1:00 pm |
Receptor Sites and Antagonists for Paralytic Neurotoxins
Dr. William A. Catterall, University of Washington
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Adjourn
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