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Abstract Abstract Title: Where physics meets biology - unlocking chromosome organization using simple polymer models Graduate Student Presenter: Susannah Gordon-Messer Name of the Author(s) and Affiliation(s): Susannah Gordon-Messer, Department of Biology; Joshua S. Martin, Department of Physics, Debra Bressan, Department of Biology; Jane' Kondev, Department of Physics; James E Haber Department of Biology Brandeis University Fixed-cell imaging combined with simple polymer models have allowed for a more detailed picture of chromosome dynamics to emerge. Through the use of 3D confocal microscopy and fluorescent markers at both th HML locus and the spindle pole body of chromosome III, we are able to examine the conformations and structure of chromosome III in yeast (S. cerevisiae). Measurements of the distance distribution combined with polymer models of chromatin reveal that an effective tether exists on the left arm of chromosome III in G1 phase yeast. Research is currently in progress to examine mutations of chromosome III which might affect its conformation. This poster will also touch on the museum outreach project designed in conjunction with this research. Picture 1: Picture 2:

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